The xME Institute is a not-for-profit institution focused on the key role of the microenvironment in driving and controlling disease. At the cellular and molecular level, the microenvironment embraces blood vessels, immune cells, fibroblasts, inflammatory cells, extracellular matrix, and signaling molecules. At the treatment level, the microenvironment lies at the heart of today’s most transformative frontiers including immuno-oncology, precision medicine, gene therapy, angiogenesis, and regenerative medicine. The Institute is highly respected for its third-party objectivity, deep scientific and clinical knowledge, and global networks of healthcare professionals and researchers. A core aim of the xME Institute is to generate expert curricula on emerging therapies that optimize pathways within the cellular and molecular microenvironment. ACCME-accredited programs give clinicians, scientists, researchers, nurses, and other scientific and medical experts state-of-the-art courses covering late-breaking clinical data and concepts.